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Dhea Can Prevent Heart Disease

If you’re 50 years old and want to avoid having a heart attack, lower your risk factors. A risk factor is anything that increases your risk of heart attack. The common ones are high cholesterol, low HDL cholesterol, high blood pressure, cigarette smoking, and inactivity. I always emphasize the importance of diet and exercise, and the reason for this is simple: It reduces your risk of having a heart attack.
Now, let’s discuss another risk factorlow levels of the hormone DHEA.
DHEA is used by your body to produce all other hormones, including testosterone, estrogen and progesterone. For reasons we don’t yet know, our production of DHEA declines as we get older, and as it drops, a host of diseases seem to come out of the woodwork, heart disease being one of them.
Low DHEA Levels Can Be a Predictor for Heart Disease
A retrospective study on heart patients found that a reduced blood level of DHEA is a specific and independent marker of heart disease. The DHEA levels of 49 male survivors of heart attacks were compared with those of 49 controls. The patients who had the heart attacks had significantly reduced DHEA levels. They remained low even when they were controlled for cholesterol, blood pressure and other risk factors.
Conventional doctors give patients drugs to lower blood cholesterol levels, blood pressure, and even to elevate a low HDL level. All of these drugs have major side effects, and it is not even proven that they reduce the risk of heart disease.
Whereas it has not been proven that elevating the DHEA level in the blood with supplemental hormone will prevent a heart attack, it is far safer and more reasonable than all the cholesterol-lowering drugs guzzled every day. Even though any physician can write a prescription for DHEA and any pharmacist can “compound” (put the hormone in a capsule) and dispense it to a patient, the only physicians who are doing this are the unconventional ones.
Why is there resistance to giving a perfectly safe, naturally occurring hormone that might ward off a heart attack? I cannot answer that, except to say that breakthroughs are simply ignored unless they happen to be a patented prescription drug.
Look for the Real Thing
There are several products on the market that are promoted as containing DHEA, but they don’t contain enough to have a measurable effect on your blood level. Additionally, many who promote the use of plant products often state that true DHEA is not available. That is obviously not true, because I have been prescribing it for many years. The prescription DHEA costs less than many of the drugs used to lower your cholesterol levelthe average cost for 50 mg per day is around $20 a month.
In the same way you measure your blood cholesterol level and blood triglyceride level, you should be measuring your DHEA level as well. If your DHEA is below the average range for your age, strongly consider supplementing with DHEA to bring your blood level up. The dose I use is 25 to 50 mg per day in women and 50 to 100 mg per day in men, while monitoring the DHEA sulfate levels.
DHEA strengthens many other aspects of your body, including brain function, energy level, and immune system. Heart disease is surely not the only condition you could be avoiding by supplementation with DHEA.
Reference:
Mitchell, LE et al. Evidence for an association between dehydroepiandosterone sulfate and nonfatal, premature myocardial infarction in males. Circulation, Jan. 1994;89:89-93.
For more information visit http://www.searchhearthealth.com

The Heart Of Heart Disease

A multi-billion-dollar industry has been built around the concept that large, cholesterol-filled blockages in the arteries cause heart attacks. That concept is just plain wrong. The reality is that as many as 80 percent of all heart attacks occur when smaller plaques, destabilized by inflammation, rupture and attract a blood clot that blocks blood flow to the heart.
So while cardiologists are placing stents to prop open large blockages or bypassing them altogether with surgery, inflammationthe real culprit in heart diseasecontinues unimpeded.
The Ins and Outs of Inflammation
Inflammation is the bodys frontline immunological response. Without it, youd fall prey to each and every infection that came along. But sometimes inflammation turns from friend to foe, and that is precisely whats going on in coronary artery disease.
Although there are many markers for inflammation, the best studied for relevance to cardiovascular disease is C-reactive protein (CRP). Studies have shown that men with the highest CRP levels have three times the risk of heart attack and twice the risk of stroke as men with the lowest levels. In women, a high CRP level is the single most important predictor of heart attack riskmore so than elevated cholesterol.
This may explain why half of heart attacks occur in individuals with normal cholesterol levels and a quarter occur in people with no risk factors at all. For these clean-living folkswho dont smoke, and dont have high blood pressure, high cholesterol, or diabeteschronic low-grade inflammation and the resulting damage to arteries may be the culprit.
A high level of inflammation isnt just a harbinger of heart attack and stroke. Research reveals that individuals who have elevated CRP levels are at greater risk of macular degeneration, hypertension, type 2 diabetes, peripheral artery disease, colon cancer, osteoporosis, and Alzheimers disease. In fact, an elevated CRP level is a marker for increased risk of premature death.
Get the Red Out
How do you reduce inflammation and, by extension, lower your risk of disease? For starters, reduce your weight to a healthy level. Fat cells are not just a parking lot for excess calories but are metabolically active, churning out hormones and inflammatory chemicals. Excess body fat, especially in the abdomen, closely correlates with chronic inflammation.
Second, eat a low-fat, high-fiber diet with plenty of antioxidant-rich fruits and vegetables and healthy fats from olive oil and cold water fish. At the same time, reduce your intake of saturated and trans fats and refined carbohydrates. In a 2004 study by UCLA researchers, postmenopausal women who followed this type of diet reduced their CRP levels by 45 percent in just two weeks.
Third, exercise. People who exercise regularly have lower CRP levels than sedentary folks. In a JAMA study, middle-aged couch potatoes who took up a walking program (just 30 minutes five times a week) reduced their CRP levels by 35 percent in only six months.
Fourth, take a high-potency multivitamin and mineral supplement. A 2003 survey of more than 14,000 Americans revealed that those with the highest blood levels of vitamins A, C, and E, selenium, beta-carotene and other carotenoids had significantly lower levels of CRP than those with the lowest levels. And in a six-month study at the Cooper Clinic, taking a high-dose multivitamin and mineral supplement lowered CRP levels 14 to 30 percent, with those with the highest levels experiencing the greatest reductions.
My Plaque-Busting Regimen
Next, get serious about oral health. Plaque that builds up in your gum line and plaque in your arteries are connected. Dental plaque causes gingivitis (inflammation of the gums), and as it progresses, your mouth becomes a breeding ground for bacteria that pass into the blood and cause inflammation elsewhere. People with gum disease invariably have higher CRP levels than those with healthy gums. They also have greater risk of heart attack and stroke.
Start by investing in a Sonicare toothbrush. Studies show that this toothbrush, which uses high-frequency vibration, outperforms its competitors in reducing the bacterial biofilms that take hold between the teeth and below the gum line. I also recommend that you use an antibacterial mouth rinse that contains chlorhexidine gluconate. (Get a prescription for Peridex or make your own rinse by combining a half ounce of Hibiclens, an over-the-counter antibacterial scrub, with 16 ounces of mouthwash.)
Another suggestion is to chew xylitol gum throughout the day, especially after meals when you cant brush. Unlike table sugar, this natural sweetener creates an unfavorable environment for bacterial growth and has been shown to reverse the progression of early tooth decay.
More Ways to Deflate Inflammation
Youve probably heard that statin drugs not only lower cholesterol but also lower CRP. However, these drugs have myriad side effects, including muscle pain and weakness, blurred vision, gastrointestinal problems, and liver damage. In fact, in a recent clinical trial, more than one in five participants dropped out during the first year and one in three disappeared by year two due to intolerable side effects of these drugs.
The real wonder drug when it comes to reducing inflammation and protecting against heart disease risk is aspirin. This little white pill relaxes the arteries, enhances blood flow, and discourages the formation of blood clots, but its anti-inflammatory effect may be its most important feature. In one study, small doses of aspirin cut the risk of heart attack in half in men with the highest levels of CRP.
Unfortunately, aspirin isnt for everyone, but there are several safe, natural anti-inflammatories. Kaprex, an herbal product that contains extracts from hops, rosemary, and olive leaf, was recently shown to significantly lower CRP levels. Fish oil (2,000 mg per day), curcumin (1,4001,800 mg), and guggulipid (2,000 mg three times a day) also curb inflammation.
Because chronic inflammation adversely affects virtually every organ system in the body, by following this program you will reduce your risk of cardiovascular disease as well as Alzheimers, cancer, macular degeneration, and other aging-related diseases.
Recommendations
If your CRP level is above 1.0 mg/L, get serious about implementing the therapies discussed here.
Look for Sonicare toothbrushes in your local drugstore or department store.
The suggested dose of aspirin is one baby aspirin (81 mg) every day, with food. Consult your doctor first if you are on Coumadin or have a stomach ulcer, an aspirin allergy, or a history of gastrointestinal bleeding.
The suggested dose of Metagenics Kaprex is one tablet three times a day.
Look for fish oil, curcumin, and guggulipid in your health food store.
References:
Church, TS et al. Am J Med. 2003 Dec 15;115:702-7.
Ford, ES et al. Eur J Clin Nutr. 2003 Sep;57(9):1157-63.
Harris TB et al. Am J Med 1999;106:506-12.
Ridker PM et al. N Engl J Med 1997;336:973-9; 2002;347:1557-65.
Smith JK et al. JAMA 1999;281:1722-7.
Wegge JK et al. Metabolism 2004;53:377-81.
For more information visit http://www.searchhearthealth.com

Coronary Heart Disease – 7 Key Steps To Cut Back Your Risk Of Coronary Heart Disease

This article will tell you what you need to grasp concerning coronary heart disease, and can provide you 7 key steps you can take, starting now, to reduce your risk of coronary heart disease.
What’s Coronary Heart Disease?
Coronary heart disease, which is also known as atherosclerosis, is a condition in which the arteries accountable for carrying oxygen to your heart muscle are blocked by accumulations of plaque. If you’re in an early stage of the disease, you probably have no symptoms, and your doctor could not even be ready to tell that you’ve got the disease. However later, when the disease has progressed over the course of the many years, it can cause sudden death because the arteries cannot get enough blood to the guts muscle to stay it functioning. Coronary heart disease ranks among the top causes of death for men and women.
What Causes Coronary Heart Disease?
There’s no single reason for coronary heart disease. However, doctors and researchers have identified certain risk factors that may heighten the danger that you will have this deadly disease. The necessary risk factors include family history, high cholesterol, obesity, smoking, and high blood pressure. Whereas you can’t modification your family history, you’ll be able to scale back your risk of coronary heart disease by controlling some of the opposite risk factors.
seven Key Steps to Reduce Your Risk
1. See your doctor for a cholesterol test and angiogram
If you’re concerned concerning the risk of coronary heart disease, begin by seeing your doctor. The doctor should take an angiogram, which measures your heart’s activity, and order a blood test that can live your cholesterol levels.
2. Lower your total cholesterol level
If your total cholesterol is over two hundred mg/dl, you ought to take steps to scale back it. Exercise and diet are the simplest means to cut back total cholesterol.
3. Exercise regularly
Most doctors currently suggest 30 minutes of aerobic exercise — like walking, jogging, swimming, or bicycling — 5 days a week.
4. Quit smoking
If you smoke, quit now. Smoking could be a significant risk factor for coronary heart disease plus for lung cancer.
5. Take a coffee-dose aspirin every day
Some proof indicates that a low-dose aspirin every day can cut back the danger of death from coronary heart disease.
6. Scale back your dietary consumption of animal fats, particularly from red meat.
Reducing your consumption of animal fat can reduce your dietary cholesterol, which in flip ought to reduce your blood cholesterol.
7. Increase your dietary consumption of contemporary fruits and whole grains.
Increasing your consumption of fruits and whole grains will also help to scale back your blood cholesterol.
Different Steps You Will Take
Additionally to the seven key steps on top of, some doctors now suppose that drinking alcohol in moderation can reduce the chance of coronary heart disease. You will want to have a drink or a glass of red wine each evening.
Doctors currently live 2 totally different types of cholesterol – HDL or “smart” cholesterol, and LDL or “bad” cholesterol. Relying on the results of your blood cholesterol test, your doctor may suggest that you just increase your HDL cholesterol level and decrease your LDL cholesterol level.
This article has outlined 7 key steps for reducing your risk of coronary heart disease. By following the steps in this article, together with your doctor’s advice, it’s very doubtless that you’ll scale back your risk of succumbing to this killer disease. Plus, you’ll get pleasure from life additional and feel higher if you create the suggested lifestyle changes.

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In Singapore Heart Disease Is Like Other Common Ailments

Coronary heart disease or atherosclerosis is a state in which the blood vessels responsible for supplying oxygen to the heart muscle, are blocked by gathering of plague. In the early stage of this disease, there is probably no symptom. That time the doctor, too, may be unable to detect it. But after duration of some years the disease may be fatal several times more and that can even cause sudden death due to the inability of the arteries to get blood enough to the muscle of the heart to maintain its functionality. Coronary heart disease is mentioned among the top most causes of death for women and men.

No sole cause is responsible for cardiovascular ailments. However, researchers and doctors have found out some particular risk factors that can enhance the risk of this type of diseases. Some of the vital risk factors include high cholesterol, family history, smoking, obesity, and high blood pressure. Though you can’t alter your family history, you can reduce your risk of coronary heart disease by restraining some of the few other risk factors.

There are seven key steps to reduce the risk of various heart diseases. They are as follows-

Doing physical exercise regularly
Lowering the total cholesterol level of the body
Quitting smoking
Taking a low-dose aspirin every day
Reducing dietary consumption of animal fats
Increasing the dietary consumption of whole grains and fresh fruits
Visiting doctor for a test of cholesterol and angiogram

Besides, some doctors think now that drinking moderated alcohol may reduce the risk of coronary heart disease. The doctors now identify two distinct cholesterols good cholesterol or HDL and bad cholesterol or LDL. Analyzing the report of the blood cholesterol test, the doctor may suggest that one should increase the HDL cholesterol level and decrease the LDL cholesterol level.

How can we detect the coronary artery disease? The coronary artery disease treatment entails various medical procedures. A good way to measure and diagnose the depth of coronary artery disease is the use of coronary angiography. It is exercised when a doctor suspects a person of having such a disease.

When the damage is caused, the body will initiate a healing process. The healing process leads the deposition of plagues at a place where the arteries are damaged. We should keep it in mind that building up of plague in the coronary arteries may begin in childhood. This plague can completely block or narrow few of the coronary arteries overtime. Finally, this condition reduces the supply of oxygen-rich blood to the muscles of the heart.

Prevention is better than cure. So, knowing the reasons of coronary heart disease is very essential. There is no substitute to early detection. Following the advice of the doctor is the best practice that we should obey to avoid few of the conditions of heart attack. Dr Lim of Singapore is a renowned heart specialist. She has a unique heart care clinic dedicated to the service of heart patients.

Is It Possible To Have A Heart Attack And Not Know It

Heart attack, or myocardial infarction, is the leading cause of death in the United States. Recent studies have confirmed that sometimes people do unknowingly have a mild heart attack. These “silent heart attacks” can lead to serious heart muscle weakness. In fact, one-in-four heart attacks may not produce any of the normal symptoms someone would associate with heart problems. In most instances, the silent heart attack isn’t life-threatening but could still cause slight damage to the heart muscles or arteries leading to the heart.

Unhealthy activities such as smoking, drinking excessive alcohol, lack of exercise and drugs often lead to issues that can cause heart attacks. High blood pressure, high blood cholesterol, diabetes and obesity are also contributors to an unhealthy heart and potentially lead to heart attack. If you live with any of the contributing factors for heart attack or heart disease, you should undergo screening for potential heart problems.

Heart Attack or Something Else?

Tightness in the chest and difficulty breathing accompanied by pain or numbness in the left arm could be symptoms of a very serious heart attack. They could also be symptoms of indigestion or acid reflux. Symptoms lasting more than five minutes could indicate a serious heart problem. No one can force you to call 9-1-1 if you suffer from any of these symptoms. However, it is highly recommended that if you feel you’ve had a heart attack, you should go to the doctor and have an EKG.

Heart Attack Prevention

Even if you’ve already experienced a heart attack, there are measures to help prevent future attacks. Obesity is one of the leading causes of heart disease and heart attack. Weight loss and exercise can dramatically decrease the risk of heart attack. Dieting, exercise and weight loss are not often easy life choices to make. Lifestyle changes are the most critical factors in surviving or preventing heart attacks. Some changes may include:

1. Blood thinning medications such as aspirin. Aspirin thins the blood and makes it less likely to clot. Blood clots cause heart attacks. Reducing the potential for clotting reduces the likelihood of heart attack. If you have already experienced heart attack, your physician may prescribe an anti-clotting drug that will help open narrowed arteries.

2. Beta blockers. By lowering heart rate and blood pressure, beta blockers reduce strain and demand on the heart itself. Many patients who have already suffered a heart attack must take beta blockers for the rest of their lives.

3. Diet and exercise. If you’ve never experienced a heart attack, diet and exercise could be the best prevention. Eating a heart-healthy diet and exercising about 30 minutes per day can strengthen the heart muscle and help maintain cleaner arteries. Obesity adds many contributing factors to heart problems. Weight loss brings with it reduced cholesterol and blood pressure, which also reduces the potential for heart attack.

4. Reduce stress. Stress is one of the leading causes of heart attack. Learn to manage your stress by reducing your workload and finding ways to minimize stress in your day-to-day activities will go a long way in preventing heart attack.

Medanta A Heart Institute Known For Unmatched Medical Care

Though, there are various ailments but Heart Disease is the most perilous where you always need for best of the best medical care services. Medanta is one of the most conjectural hospitals in India, located in Gurgaon, provides prodigious medical care services to patients. This is the major reason why patients come from different parts of the world to get extraordinary medical treatment at reasonable prices.

The heart institute in Delhi aims at diminishing the shouting number of cardiovascular diseases through advanced and state of the art programs in patient care. The institute is home to globally recognized doctors, experienced cardiac surgeons, nurses, technicians and heart experts obligated of extreme excellence in patient care, education and research.

Dr. Vijay Kohli is a renowned heart surgeon India and director of Cardiac surgery at Medanta Heart institute in Delhi. With the employment of latest technology and treatment methods the Medanta Heart institute in Delhi is patient-centric and includes academic department which aims at helping the patients and advancement of life science through education and research.

Now browsing from the list of best cardiac surgeons in India is relatively much easier with Medanta. Here, the team comprises of well-recognized surgeons and doctors who have abundant experience in treating cardiovascular diseases. Medanta Heart Institute performs cardiac surgery using:
Latest technology including Hybrid Operating Suit,
Robotic Heart Surgery
Strictly Invasive Valve and Coronary Heart Bypass techniques.

Delhi is a famous place where one can locate various world class hospitals including Escorts Heart Institute, AIIMS, Fortis, Apollo and others. A good hospital not only aims at dealing a dangerous disease but enabling the patient to come out of that severe condition and to promote overall health and wellness. Although, there are a large number of cardiac surgeons in India but going to a hospital is a wise option which also gives an added advantage of trust and technology.

Overcome Your Heart Diseases And Diabetic Complications

The countries like the United States are suffering with a number of death cases due to heart disease every year. The term of this disease has many types and segments that generally affect the heart. Some of the heart disease that are very common like heart disease due to high blood pressure , Coronary Heart Disease , Ischemic Heart Disease , Tachycardia , heart murmurs etc. The heart diseases like the vascular heart disease, colonial heart disease and others can be cured completely. The main cause of a heart disease is mental stress, high blood pressure or hypertension, high level of cholesterol, overweight and/or obesity and many cases the heart disease also occurs due to stress. The habit of excessive smoking or a heavy intake of alcohol is also a great reason of heart diseases. The occurrence of heart disease is also affected by gender and sex. It also occurs due to hereditary issues. In many cases, it has been observed that if in a family , one of the parents are suffering with any sort of heart disease, the children can also be affected. Nowadays, the occurrence of heart disease also has roots in the growing environmental changes and pollutions and other toxins. Many of the stressful situations help to increase the blood clotting in the heart and also lead to hypertension. Some of the sex hormones are also responsible for a heart disease. The women who are in the age of sixty-five or seventy or in the menopausal condition face a drastic change in the sex hormones and have severe kinds of sickness in the heart.

The PSA tests are done especially in case of a cancer in the prostrate in males. The PSA is actually a type of protein, which is known as Prostrate-specific antigen. Antigen is manufactured in the prostrate. The test actually measures the level of this type of protein in the human blood. Thus, this test is done by taking a blood sample. The PSA medically is also known as tumor marker or biological marker. The US Food and Drugs Administration or FDA also has approved the medical use of PSA test. In the test process, the physical experts take blood from the veins, usually from the elbows. Here, the medical experts first clean the place from where he is going to take the blood and the enfold the upper portion of the arm with a band, then he gives pressure on the affected part to let the veins swell with blood and then he takes a particular amount of blood from the body. The medical experts say that the test can be useful if done including a Digital rectal Exam or DRE, especially in case of a prostrate cancer in those patients who are either 50 years old or more than that. In the DRE test process, the medical experts verify the prostrate gland the rectal wall to check the blisters and other abnormal growths. The FDA has also approved that the PSA test also can be useful if a person has a case of re-occurrence of prostrate cancer.

The person who suffers with a high level of blood sugar is diagnosed with diabetes. The condition of diabetes can also interrupt in the functioning of other body parts. The reason of the various complications of diabetes has its roots in some of the other body functions and some of the medicinal affects on the body. It is very widespread in the United States. Many of the patients do not even know that have the sickness. This is a sickness where the human body faces problem to keep a balance between the sugars and is not able to use insulin in an adequate amount. The insulin is a type of hormone, which helps the body to convert the level of starches, sugar and many of the other food into energy to boost the other body cycles. If a person has an invariable level of high amount of glucose, it is been said that the person has diabetes. The diabetic person will also have difficulties in the functions of eyes, heart, feet and even on the liver and kidney. The diabetes Mellitus mainly cause the condition of diabetes. The sickness generally is of three types, Type 1 diabetes, and Type 2 and Gestational diabetes.

How to reduce your risk for Heart Disease the Natural Way

Are you one of the millions of people that is suffering from heart disease or even worse? Have already experienced a heart attack.

These days its difficult not to meet someone who is either suffering from heart disease, has had a heart attack or has been told they are at risk for heart disease. Its just about as common as meeting someone with brown hair. Unfortunately, the media and even many well-meaning doctors are completely misinformed on how to tackle this growing epidemic. Its the number one killer in the US and plaguing many other countries as well.

What are we to do?

The best plan of attack is to combat the risk factors the best we can.

Use the following 5 tips to get you started on a heart healthy plan:

1. Drop the smokes. Yes, smoking has been shown to be one of the biggest risk factors in heart disease, mainly because of all the toxic chemicals added to cigarettes (not that Im recommending tobacco or anything.)

2. Walk, walk, walk. If finding time for a structured exercise program is just too much of a challenge right now, just start by walking. I have known many people who have strengthened their heart and reversed severe conditions by getting outside and walking. If you can, find a scenic route. Theres

nothing more calming than the outdoors. (I highly recommend whistling and singing while you walk. It makes for happy thoughts.)

3. Calm down. By this I mean, dont stress about the stuff you dont have to. This is actually a very funny statement coming from me who used to stress about everything! Deadlines, laundry, work, family you name it, I stressed about. Not until I realized that this would kill me no matter how healthy my food was did I drop the stress and pick up the laughter. Right now as I write this newsletter, Ive got more things that need to get done today than are humanly possible. My reaction “Haha..better put my Superwoman shirt on”

4. Do not and I repeat, do not go on a low-fat diet. Your heart condition may get worse in your attempts. Drop the bad fats (like hydrogenated oil and the nasty oil in French fries and donuts) and start eating more healthy fats like coconut oil, olive oil, salmon, walnuts and whole organic eggs.

5. Do not be afraid to eat saturated fat. If read “The Truth About Saturated Fat” in The Diet Solution Program you know that eating saturated fats is not what is causing people to get heart disease. It is processed foods, sugars and an overabundance of refined carbohydrates that is making this country so sick. The whole saturated fats topic gets me so fired up, I even made a video to further inform you check it out here: http://www.dietsandweightlossreviews.com

Cardiovascular Center Innovative Trials And Screening For Advanced Heart Disease

Directed by Kenneth L. Baughman, MD, the Advanced Heart Disease Program part of the Cardiovascular Center is comprised of a multidisciplinary team of leading specialists dedicated to the care of patients with congestive heart failure and other severe cardiac conditions. New clinical trials at the Program include:

Jarvik 2000 Heart Assist System Gregory S. Couper, MD, and James Fang, MD, are directing this trial assessing a new ventricular assist device (VAD) that is quieter, smaller, and more durable compared with older generation VADs. Patients with end-stage congestive heart failure who are failing medical therapy and considered appropriate candidates for cardiac transplantation may qualify for this clinical trial. (For more information, please call Gregory S. Couper, MD, at 617-732- 7678 or email .)

OPCAT For patients with diastolic heart failure, this National Heart, Lung, and Blood Institute (NHLBI)-sponsored, international multicenter trial is testing the efficacy of an aldosterone antagonist in the treatment of heart failure patients with preserved ejection fraction. Patients 50 years of age or younger with a left ventricular ejection fraction of less than or equal to 45 percent and signs and symptoms of heart failure with either a heart failure hospitalization in the past 12 months or elevated brain natriuretic peptide levels are eligible for the study. TOPCAT is led internationally by Brigham and Womens Hospital senior cardiologist Marc A. Pfeffer, MD, PhD, and locally at Brigham and Womens Hospital by Dr. Fang, along with Eldrin F. Lewis, MD, MPH, Scott D. Solomon, MD, and Akshay S. Desai, MD. This trial is only the second major trial that has offered a medical therapeutic option for patients with diastolic heart failure. (For more information, please contact Eldrin F. Lewis, MD, MPH, at 617-525-7057 or , or James Fang, MD, at 617-732-7367 or .)

HF-ACTION (Heart Failure A Controlled Trial Investigating Outcomes of Exercise Training) Sponsored by the NHLBI, this randomized, controlled, multicenter trial is designed to evaluate the impact of exercise on advanced heart disease, including its effects on mortality, morbidity, hospitalizations, and over- (continued on page 6) all quality-of-life. Class II, III, and IV systolic heart failure patients with ejection fraction less than or equal to 35 percent may qualify for participation in this trial, that is overseen locally in three locations by Brigham and Womens Hospital specialist Daniel E. Forman, MD. (For more information, please call Research Study Coordinator Maria M. Lopez, MA, at 617-525-7638 or .)

Milestones in Transplantation
Adding to a long history of accomplishments in organ transplantation at Brigham and Womens Hospital, specialists completed the Cardiovascular Centers 500th heart transplant in December 2005 more than any other center in New England. Brigham and Womens Hospital physicians performed the first heart transplant in New England more than 20 years ago and the worlds first successful human organ transplant in 1954.

Cardiovascular Genetics Center
The Cardiovascular Genetics Center also part of the Cardiovascular Center offers comprehensive evaluation, diagnosis, and management for individuals and families with hypertrophic cardiomyopathy (HCM), familial dilated cardiomyopathy (DCM), inherited aortic aneurysms, inherited arrhythmias (including QT syndrome), and Marfan syndrome. Center Director Christine E. Seidman, MD, and Medical Director Carolyn Ho, MD, along with other Center clinicians, provide:

Individual genetic screening with clinically approved DNA analysis;

Family screening;

Genetic counseling;

Risk stratification for sudden cardiac death.

Disease-specific experts carefully monitor patients with genetic mutations for cardiac disease, and early medical intervention is available to delay the onset of disease. Careful longitudinal evaluation may also prevent or minimize the incidence of high risk cardiac events and sudden death. The Center is currently evaluating patients with pre-symptomatic hypertrophic myopathy in an effort to avoid development of the disease.

Information and Referrals
To refer a patient to the Cardiovascular Center at Brigham and Womens Hospital, please call a Referral Coordinator at (617) 732-9894.

Know More About The Ischaemic Heart Disease

The heart is one of the most important organs and holds the job of pumping blood to other organs. Ischaemic heart disease also referred to as myocardial Ischemic is a heart disease that affect the way how the blood goes to the heart. Ischaemic heart disease occurs when there is a plaque formation that restricts the arteries from sending precious blood and oxygen to the heart. The heart becomes affected when there is not enough in the blood circulation to the heart muscle which injures the heart muscle. Ischaemic heart disease has become one of the leading causes of death in the western hemisphere.

Ischaemic heart disease is very unlikely to show any signs in its first when it starts to take effect however, produces various symptoms can be seen based on the codition of the disease when it is diagnosed. Some the most identifiable symptoms are acute chest pain and angina prectoris. Acute chest pain can be described as an extreme pain felt in chest and is dealt with an emergency situation.

Angina precoris causes persons to feel chest pain behind the breast bone or slightly to the left of the chest, there may also be a crushing sensation, squeezing or heavy pressure spreading to the jaw, back, shoulder or event the arms. This symptom also causes indigestion, light headedness, vomiting, shortness of the breath. Its a possibility that angina precoris will not show any of these symptoms even when in effect; this is known as silent ischaemia. Ischaemic Heart Disease can also lead to heart failure gradually over time. Heavy coughing, shortness of breath with after resting or while exercising, fatigue, loss of appetite, irregular pulse, swelling of the ankles and feet are all signs that a heart failure may be impending.

There are certain particular habits that makes it easier of you getting heart diseases. Individuals who have particularly bad eating habits and suffer from obesity automatically increase their chances of being affected by these heart disease. These situations cause high cholesterol levels that make the heart overwork to keep up with the needs of the body and so leads to various heart diseases.

Individuals experiencing situation should maintain healthy eating patterns and exercise for at least three times during the week and maintain your body mass. These habits can greatly minimize stress levels, massages the muscles and keeps the body in check. Individuals that suffer from poor sleep, and dont work out are more prone to feel highly stressed. Cigarette smoking is also a huge contributing factor of heart diseases. If persons hope to minimize their chances of getting Ischaemic heart Disease, smoking will have to be stopped. High stress levels can also lead to ischaemic heart disease,Persons who have experienced a stroke or heart attack or who have a family history of heart diseases or other illnesses such as diabetes are more likely to experience a heart diseases. So Persons should make it their duty to research their medical history and seek a heart specialist when necessary to test the condition of their blood pressure and cholesterol levels. They should also be conscious of what they eat. Individuals may require medications to regulate these conditions. In severe cases of Ischaemic heart Disease, operation may also be required to treat ischaemic disease but the best remedy is prevention by exercising healthy lifestyle habits.